Jason Hope Funds the SENS Foundation’s AGE Breakers Program

Jason Hope donated more than $500,000 to fund anti aging research funding to establish the SENS Laboratory in Cambridge and to jump start the AGE breaker program. The SENS Foundation, headed by Dr. Aubrey de Grey, is currently developing AGE breakers which are treatments and pharmaceuticals that have the ability to catabolize or break down molecules produced by advanced glycation. Glycation occurs due to the bonding of a sugar molecule to a protein or fat molecule, without an enzyme. Enzymes are crucial because they help regulate and control how the molecules bond to one another.

These molecules, known as AGES or advanced glycation end products are waste products that build up within the tissues. Some of the AGEs are benign and others are toxic to the body. The harmful AGEs cause progressive damage and loss of functioning to tissues. Examples of this damage include the ability of elasticity in blood vessels and in the skin.

AGEs are associated with many chronic diseases that are age related such as cardiovascular diseases. In these diseases, damage is caused to fibrinogen, endothelium and collagen. An important example of this is atherosclerosis. The end result of the action of AGES is losing elasticity within the blood vessels. Atherosclerosis is more commonly referred to as hardening of the arteries due to the depositing of fat on the walls of blood vessels. This occurs through the destruction of macrophages that are sent to the cell walls of the arteries by AGEs. The purpose of the macrophages is to clean up and remove waste products such as AGEs that are made of mostly cholesterol. Instead, the AGEs poison the macrophages and fat molecules builds up within the arteries. The arteries lose elasticity, constrict the arteries, and limit the flow of blood throughout the body. Blockage of the arteries can lead to stroke and heart attacks.

References: www.facebook.com/public/Jason-Hope

Des Perez – The Most Powerful Woman at Roc Nation

The music industry is truly a giant in the world of business. It is surprising that until recently women were excluded from executive positions at record labels and in other parts of the music industry. It is only in recent years that women were able to push themselves into the backrooms and board meetings of some of the most profitable record labels in the world.

Desiree Perez has known the entertainment world for far more time than most women in the industry. She has been an associate of Jay-Z for over two decades. Jay-Z, whose real name is Shawn Carter, has trust Desiree Perez to handle things such as the recruitment of new athletic talent to tours and events for musical talent.

Currently, Perez is the COO of Roc Nation, Carter’s record label. At the label, Perez’s responsibilities consist of working with talent, arranging tours and events, and making contact within the music industry. During her time at Roc Nation, Perez has had the oppurtunity to work with such musical acts as Mariah Carey, Kanye West, Beyonce, Rihanna and Jay-Z himself.

The success of Jay-Z’s newest album, “4:44”, is partially a success because of Perez. She recently made a 200 million dollar deal with Sprint that enabled subscribers of Sprints cellphone service to download “4:44” for free. A similar deal was reached with Samsung for Jay-Z’s previous work, “Magna Carta Holy Grail.” Both deals made it possible for Jay-Z to sell 1 million units before either album had even been released.

As previously mentioned, Roc Nation is not only a record label, it is also an athletic management agency. Their clients consist of legendary athletes such as Miguel Cotto and Kevin Durant. On March 1st, 2018 Roc Nation announced one of its newest talent acquisitions, Romelu Lukaku.

Learn More: www.instagram.com/des.perez/